Review
Open access
Jul 2026
Methylglyoxal as a Convergent Mediator of Diabetic Complications: Generation, Protein Targets, Tissue Distribution, and Therapeutic Reduction—A Clinically Oriented Mechanistic Synthesis
It is proposed that routine parameters such as gamma-glutamyl transferase and red cell distribution width may serve as accessible proxies for MGO burden, with the explicit caveat that these mappings require prospective validation and do not constitute a validated clinical instrument.
Enrique C. Fernandez
· Biomolecules · 0 citations