Open access
Sep 2026
The DNA/RNA Helicase SETX Maintains R‐Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer
ABSTRACT Ovarian cancer is a lethal malignancy that frequently develops resistance to platinum‐based chemotherapies. Elucidating the genes that regulate DNA damage repair could lead to more effective treatments for ovarian cancer. Senataxin (SETX), an RNA–DNA helicase, maintains R‐loop homeostasis to ensure replication...
Zi-Wei Hu, Tu-Nan Xu, Zi-Ying Wang et al.
· Cancer Science · 0 citations