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Author

Eric Chevet

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Open access Sep 2026

CReP-mediated control of eIF2α phosphorylation is a critical node in MYC-driven medulloblastoma

Medulloblastoma (MB) is the most common malignant pediatric brain tumor. The MYC‑amplified group 3 (G3) MB represents a high‑risk disease lacking effective therapies. A genetic screen identified the endoplasmic reticulum chaperone HSPA5 (BiP/GRP78) as a critical dependency in G3 MB. Its silencing induces apoptosis and...

Liliana Mirabal-Ortega, Sandra Majo, Lucie J. Taunay et al. · 0 citations
Review Oct 2026

The unfolded protein response in precision oncology: from mechanisms to therapeutic opportunities.

The unfolded protein response (UPR) is a fundamental stress pathway coopted in cancer, and it is thought to drive adaptation, tumor progression, and therapeutic resistance. While the analysis of 'single-effector' biomarkers within the tumor microenvironment often fails to capture its spatial, temporal, and cellular com...

Quentin Bourgery, D. Doultsinos, A. Galmiche et al. · 0 citations
Review Oct 2026

Responses to endoplasmic reticulum stress at a glance.

The endoplasmic reticulum (ER) is the gateway to the eukaryotic protein secretory pathway. Beyond its role in protein biogenesis, it is central to Ca2+ homeostasis and lipid biosynthesis. This organelle, which can constitute more than 50% of the cellular membranes in secretory cells, is highly plastic and must adjust t...

Eric Chevet, C. Philippe, T. Avril et al. · 0 citations
Editorial Open access Aug 2026

The (European) protein homeostasis network

This review series highlights the breadth and impact of European research in the field of proteostasis, spanning fundamental mechanisms, organelle‐specific quality control pathways, and emerging therapeutic opportunities and showcases the collaborative efforts that have strengthened the European proteostasis community.

Eric Chevet · 0 citations
Open access Jul 2026

COMPASS: A Computational Pipeline to Identify Linkers Predicting Ubiquitinable PROTAC‐Induced Ternary Complexes

PROteolysis TArgeting Chimeras (PROTACs) are bifunctional molecules designed to induce targeted protein degradation by forming a transient ternary complex between an E3 ubiquitin ligase and a protein of interest (POI), leading to the E3‐mediated ubiquitination of the POI and its subsequent proteasomal degradation. Alth...

Sébastien Sueron, S. J. Mahdizadeh, Eric Chevet et al. · 0 citations

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