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Author

Eric L. Van Nostrand

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Aug 2026

Oncogenic KRAS Rewires mRNA Stability and Translation through AGO2-Mediated Disruption of the miRNA pathway.

KRAS mutations occur in over 90% of pancreatic ductal adenocarcinomas (PDACs). Despite recent advances in targeting oncogenic KRAS, tumors eventually acquire resistance. A more comprehensive understanding of the mechanisms connecting KRAS signaling to tumor progression could facilitate the development of effective ther...

Z. Yang, Angelina S. Bortoletto, Mara G. Cardenas et al. · 0 citations
Open access Aug 2026

Kinetic Control of Nuclear-encoded Mitochondrial mRNA Localization and Local Translation

These experiments and modeling suggest that the process of local translation at the OMM is kinetically controlled by the cell, and reveal an unappreciated mechanism by which active transport of RNAs enables cells to modulate their translation within minutes through RNA localization control.

Surbhi Sharma, Xue-Mei Wang, Steven Nguyen et al. · 0 citations

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