Author

Eric Largy

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Open access Aug 2026

A protein–foldamer supramolecular synthon for self-assembled hybrid architectures

Constructing artificial assemblies that combine proteins and synthetic ligands has been hampered by the lack of protein–ligand interfaces that are sufficiently large and organized to enable precise structural control. Here ribosome display selection is used to identify a protein that binds a helical aromatic foldamer b...

Johannes Sigl, Vasily Morozov, Ling-Fei Wang et al. · Nature Chemistry · 1 citation

Open access Sep 2026

Native Hydrogen/Deuterium Exchange Ion Mobility Mass Spectrometry of Structured DNA Oligonucleotides

IMS is established as an essential tool for complementing HDX/MS in the characterization of structural polymorphism and conformational ensembles in DNA oligonucleotides and can be leveraged to distinguish groups of non-specific cation binding on a given conformational ensemble.

Matthieu Ranz, Romane Guisiano, Eric Largy et al. · bioRxiv · 0 citations

Open access Jul 2026

Dibenzoacridinium derivatives: a new class of G-quadruplex ligands with anti-HIV-1 properties

The design, synthesis, and biophysical characterization of a novel class of G4-stabilizing ligands based on a positively charged dibenzoacridinium (DBA) core are reported, identifying DBAs as a new class of G-quadruplex ligands with anti-HIV properties.

Aman Kabbara, C. Buré, A. Guédin et al. · RSC Medicinal Chemistry · 0 citations