An unbiased atlas of the whole cell and surface proteomes of 25 commonly used leukemic cell lines, encompassing both lymphoid and myeloid lineages, and a variety of driver mutations, is presented, creating a resource for understanding these widely used models.
Benson M. George, Anna Rodríguez-Pöhnlein, D. DeCastro et al.· bioRxiv· 0 citations
Cysteine residues are critical for both the catalytic activity and structural stability of many proteins, yet their high chemical reactivity threatens proteome integrity. Whether cells have specialized mechanisms to recognize and eliminate proteins with aberrant or exposed cysteines is unknown. By systematically analyz...
Elijah L. Mena, Ken C. Dong, Anthony Kairouz et al.· bioRxiv· 0 citations
Combined genome-wide CRISPR knockout screening with base editor tiling screens at amino acid resolution reveal molecular rules governing HUWE1 phospho-degron recognition and identify a regulatory gate controlling substrate engagement and illustrate a generalizable strategy for resolving degradation mechanisms of undrug...
Keita Masuzawa, Kevin D. Dong, Calvin XiaoYang Hu et al.· Genes & Development· 0 citations
It is established that metabolically activated compounds can redirect E3 ligase function, thereby expanding the scope of targeted protein degradation and chemically induced proximity.
Hojong Yoon, F. Wachter, Katharine A. Barrett et al.· Nature· 1 citation
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