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Author

Eric Tse

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Open access Sep 2026

Cryo-EM Structures of Infectious Low-Twist α-Synuclein Filaments in Lewy Bodies

It is established that low-twist filaments, which include over 75% of disease-associated Lewy aSyn amyloids, share a common structural core with high-twist forms and are the predominant aSyn species in samples that engage in templated infection.

Nicholas L. Yan, Mylan Mayer, Arthur A. Melo et al. · 0 citations
Open access Aug 2026

Cofactor-Free Tau Filaments Are Dynamic and Undergo Structural Evolution Driven by Thermodynamic Control

Environmental factors, such as mechanical stress and/or polyanions, play an important role in promoting the thermodynamic stability of otherwise dynamic tau fibrils, and it is speculated that, in patients, such factors might contribute to the maturation of disease-specific conformers.

Wyatt C. Powell, Nicholas L. Yan, Eric Tse et al. · 0 citations

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