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Erin L. Li

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Open access Sep 2026

Paired CYP1A2/3A4-HepG2 phenotyping supports machine-learning classification of literature-curated hepatotoxicity categories.

Limited CYP1A2/3A4 activity in wild-type HepG2 cells can obscure hepatotoxic responses that require metabolic activation. We established matched CYP1A2/3A4-co-expressing and empty-vector (EV) HepG2 cells and profiled 81 compounds with six high-content imaging readouts and three extracellular injury biomarkers. Absolute...

Erin L. Li, Jing Long, Ting Yu et al. · 0 citations

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