Author

Erling Hu

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Open access Jul 2026

β-hydroxybutyrate restores social deficits by suppressing HDAC9 in the ACC of Shank3B-deficient mice.

It is found that KD ameliorates social deficits and induces systemic ketosis with marked elevation of β-hydroxybutyrate (BHB) in KO mice, and HDAC9 is identified as a potential therapeutic target for ASD-related social deficits.

Erling Hu, Jialong Li, Chuchu Qi et al. · EMBO Molecular Medicine · 0 citations