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Esra Basaran

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Open access Oct 2026

PDI-Spot: A Robust Representation Learning Framework for Identifying Energetic Hotspots in Protein–DNA Complexes

The binding affinity of protein–DNA complexes is concentrated within a subset of interface residues, called “hotspots”, which are critical for maintaining stable interactions. Therefore, identifying these energetic anchors is essential for elaborating on how mutations disrupt transcriptional regulation and for identi...

Esra Basaran, A. Gursoy, Ozlem Keskin et al. · 0 citations

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