Ethan S. Lippmann

Conditional Mutant MAPT Overexpression in Neural Organoids Elicits Robust Tau Accumulation and Pathological Transcriptomic Responses

This study developed an iPSC line harboring doxycycline-inducible mutant MAPT, which encodes the microtubule-associated protein tau that is implicated in tauopathies, and developed an approach for controlling the initiation and progression of proteinopathy-like pathology in neural organoid systems.