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Open access Sep 2026

Ginsenosides Rb1 and Rg1 Suppress Lipopolysaccharide‐Induced Inflammatory Gene Expression in Microglia and Astrocytes, Unlike Rb2

ABSTRACT Neuroinflammation, mediated by activated microglia and astrocytes, contributes to the progression of neurodegenerative diseases. Ginsenosides derived from Panax ginseng possess anti‐inflammatory properties. However, the comparative efficacy of structurally distinct ginsenosides and their activity across multip...

Hanwoong Woo, Jeong-im Choi, Sohee Kim et al. · 0 citations
Open access Sep 2026

Selpercatinib mitigates microglia-mediated neuroinflammation by inhibiting RET signaling and NLRP3 inflammasome activation

Background Selpercatinib is a highly selective rearranged during transfection (RET) receptor tyrosine kinase inhibitor approved for RET fusion-positive cancers and known to penetrate the blood–brain barrier. Although RET signaling has been implicated in neural development and cell survival, its role in microglia-mediat...

Jung-Ki Min, D. Park, Hanwoong Woo et al. · 0 citations

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