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Open access Sep 2026

Harmine Plus Exendin-4 Enhances Remission of Recent-Onset Type 1 Diabetes Following Anti-CD3 Therapy

Type 1 diabetes (T1D) results from autoimmune destruction of pancreatic β-cells. While anti-CD3 therapy can delay disease progression and preserve residual β-cell function, disease reversal will likely require both immune modulation and β-cell regeneration. We found that the combination of harmine and exendin-4 (H+E) r...

Ge-Ming Lu, Randy B. Kang, Miguel A. Varela et al. · 0 citations
Open access Jul 2026

Extracellular vesicles from cytokine-treated human pancreatic ductal cells enhance HLA class I expression in beta cells

Introduction/objective Type 1 diabetes (T1D) is an autoimmune disease characterized by the loss of insulin-producing beta cells and has no cure. The role of cell-cell interactions in T1D disease progression remains poorly understood. Beta cells develop adjacent to ductal cells and both cell types undergo changes during...

Neslihan Erdem, H. Zook, Janine C. Quijano et al. · 0 citations

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