Author

Evan C. DeTurk

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Open access Jul 2026

Structure and evolution-guided design of minimal RNA-guided nucleases.

A protein design strategy is used that couples a structure-guided inverse-folding model with evolution-informed residue constraints to generate active, divergent variants of TnpB, a minimal CRISPR-Cas12-like nuclease, termed SynTnpBs, establishing a strategy for creating non-natural RNA-guided nucleases and conformationally active nucleic acid binders, enlarging the designable protein space.

Petr Skopintsev, Isabel Esain-Garcia, Evan C. DeTurk et al. · Science · 2 citations