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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Evan S. Swanson

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Open access Aug 2026

Adolescent stress recruits a latent amygdala-dopamine circuit to drive punishment-resistant reward-seeking

Adolescent stress is a lifelong risk factor for addiction, but the underlying neural circuit changes remain unknown. Here, we show that chronic unpredictable stress in adolescent mice causes a prominent increase in punishment-resistant reward-seeking – behavior tightly linked to the diagnostic criteria for addiction –...

J. Nadel, Evan S. Swanson, Manhua Zhu et al. · 0 citations
#reinforcement learning Open access Sep 2026

Cholinergic-dependent dopamine signals in mouse dorsomedial striatum are regulated by frontal but not sensory cortices

Everyday decisions depend on associations between sensory stimuli, actions, and outcomes. The striatum supports these sensorimotor associations through dopamine-dependent plasticity. Recent work has characterized a local striatal microcircuit in which cholinergic interneurons (CINs) modulate dopamine release via activa...

Hannah C. Goldbach, Rachele Rimondini, Evan S. Swanson et al. · 0 citations

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