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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Evelyn Hennigan

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Open access Aug 2026

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains

An iPSC-based 3D model that integrates neurons, glia, myelin, and cerebrovascular cells into a human brain-like tissue (“miBrain”) is developed and establishes a robust model for investigating protein inclusions in human iPSC-derived brain tissue.

Louise A. Mesentier-Louro, Camille Goldman, Sebastian Gaese et al. · 2 citations
Open access Jul 2026

Single-nucleus analysis of the adult human olfactory epithelium uncovers shared neurogenesis programs with the brain

It is shown that the adult olfactory epithelium recapitulates key transcriptional and regulatory programs of cortical neurogenesis, providing an accessible model for studying psychiatric disease-associated neurodevelopment.

Liting Song, J. Fullard, Claire Coleman et al. · 0 citations
Open access Aug 2026

Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease

It is shown that a disease-associated microglial subtype, characterized by elevated GPNMB expression and enriched for polygenic AD risk, expands with AD pathology and shows increased phagocytic activity, and MITF is identified as an upstream regulator required to maintain this microglial state.

Donghoon Lee, James M. Vicari, Christian Porras et al. · 1 citation

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