Enhancers control tissue-specific gene expression across animals1. Although deep learning2,3 has enabled enhancer prediction and design in mammalian cell lines and non-mammalian model organisms4, 5, 6, 7, 8, 9–10 (reviewed in a previous publication11), it remains unclear whether such approaches can operate within the r...
Shen-Zhi Chen, Vincent Loubière, Ethan W. Hollingsworth et al.· Nature Genetics· 1 citation
It is shown that increased ovarian area contributes to both PMOS susceptibility and ovarian cancer progression, while specific ovary-heart signaling circuits modulate cardiac function with aging, and SF3B1-mediated splicing is uncovered as a link between ovary function and systemic metabolism.
Christy M. Nguyen, L. Velez, Youngseo Cheon et al.· Journal of Clinical Investig...· 0 citations
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