F. Alqahtani

Vitamin B6 augments antidepressant activity of venlafaxine by restoring cortical EEG oscillations, behavior and oxidative biomarkers in chronic unpredictable mild stress (CUMS)-induced model of depression-like behavior.

Depression is a multifactorial neuropsychiatric disorder associated with chronic stress, disrupted neural oscillations and oxidative stress. The present study investigated whether vitamin B6 (Vit B6) enhances the antidepressant efficacy of venlafaxine (VEN) in a chronic unpredictable mild stress (CUMS)-induced model of...

Development and Evaluation of Physiologically Based Pharmacokinetic (PBPK) Models of Metoclopramide Across the Lifespan: Translation from Adults to Infants

Background: Physiologically based pharmacokinetic (PBPK) modeling is an established approach used in recent years for estimating drug disposition in challenging clinical scenarios where in vivo studies are difficult to perform. Metoclopramide is a benzamide derivative, widely indicated for its antiemetic and prokinetic...

A systematic review of the clinical pharmacokinetics of fluconazole in healthy and diseased populations.

INTRODUCTION Fluconazole is a triazole antifungal agent commonly used to treat both systemic and superficial fungal infections. This comprehensive review aims to collate all published pharmacokinetic (PK) data on fluconazole in healthy and diseased subjects. METHODS A systematic search of Google Scholar, PubMed, and...

Metabolic and redox modulation by 2-deoxy-D-glucose and sodium selenite protects against pentylenetetrazole-kindled seizures, neuroinflammation and cognitive dysfunction

EGONet: edge guided omni-directional attention with multi-scale bilateral feature integration for surface defect detection

Surface defect segmentation (SDS) is challenging in automated inspections due to the high variability of defects amid complex metallic textures. The defects show significant variations in size, shape, contrast, and spatial distribution. Existing segmentation methods struggle to jointly model fine boundary cues, omni-di...

Exploring the Clinical Pharmacokinetics of Sitagliptin in Healthy and Diseased Populations: A Systematic Critical Review.

The available PK data on sitagliptin from published studies in healthy and diseased subjects are summarized and may be useful for developing physiologically based PK models and may provide additional information to support clinicians in optimizing sitagliptin dosing in patient populations.

Vitamin B12 and pregabalin combination restored brain waves dynamics and behavior in chronic unpredictable mild stress (CUMS) model of depression.

The use of multimodal network therapy to manipulate neurophysiological resilience in thalamocortical and corticocortical circuitry to modulate depression-like phenotypes and relapse in LLD patients is supported.