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Aug 2026

Immunometabolic endotypes define distinct clinical trajectories in type 2 diabetes.

Type 2 diabetes (T2D) is a heterogeneous disease, yet current classifications do not capture its clinico-biological complexity or support precision-based care. We developed an endotyping strategy based on routine blood immune cell counts across more than 1,500 individuals with newly diagnosed T2D from three European co...

B. Vuong, Chloe Delepine, Jacqueline M. Ratter-Rieck et al. · 0 citations
Review Open access Aug 2026

Epigenetics, bacterial metabolites and type 2 diabetes: a new view of gut-genome interactions

Gut microbial metabolites are active regulators of chromatin architecture and metabolic gene networks that influence the risk, development and progression of T2D, supporting a conceptual shift in understanding of T2D biology.

Aqeel F. Taqi, Ahmad Albuloushi, Ayat Saleh et al. · 0 citations

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