F. Bartolomei

A whole-brain modeling framework for tDCS montage optimization in drug-resistant epilepsy

Transcranial direct current stimulation (tDCS) is a promising non-invasive therapy for drug-resistant epilepsy, but the montage optimization pipelines used to personalize it often rely on biophysical head models that capture only the induced electric field and ignore the network dynamics through which stimulation influ...

Higher-order interdependencies of the epileptogenic network in presurgical resting-state fMRI

Drug-resistant focal epilepsy (DRFE) is understood as a complex brain network disorder. As a result, conventional pairwise functional connectivity may fail to capture the higher-order interactions between groups of epileptogenic regions. We applied multivariate information theory to stereotactic electroencephalography-...

Localizing value of ecstatic phenomenon in epilepsy surgery: A systematic review.

OBJECTIVE A systematic review was conducted to synthesize current anatomo-clinical correlations of ecstatic symptoms in focal epilepsy, aiming to provide evidence-based guidance for interpreting this ictal semiology during presurgical evaluation. METHODS We searched PubMed and Web of Science using terms related to ec...

Causal mapping of self-motion networks in the human brain

Unveiling Functional Architecture of Human Thalamus: AStereoelectroencephalography Study

As a critical hub in the thalamo‐cortical circuit, the human thalamus engages in a spectrum of fundamental and advanced brain functions through widely distributed circuits. Clinically, dysfunction of thalamo‐cortical circuits is shown to be profoundly implicated in a wide range of neurological and psychiatric diseases....

Hippocampal Seizure-Related Burden is Associated with Accelerated Long-Term Forgetting in Focal Epilepsy.

Higher dominant-hemisphere hippocampal burden was associated with poorer 1-week verbal memory (performance and retention), independently of most covariates, and is a major predictor of impaired long-term verbal memory consolidation in focal epilepsy.

The burden of the postictal state in epilepsy: A prospective, single-center observational cohort study.

Greater postictal severity, particularly concerning anxiety and depression, is associated with interictal psychiatric comorbidity, while altered temporal experience emerges as a distinct dimension of postictal dysfunction.

Surprise gates two distinct mechanisms to support memorability in music

Analysis of the neural correlates of minutes-scale memorability using intracranial EEG recordings from nine patients with epilepsy performing a musical memory task reveals complementary neural mechanisms through which statistical structure shapes musical sequence memory, clarifying how the brain encodes complex, ecolog...