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Sep 2026

Abstract B003: Developing an all-human model of perineural invasion in pancreatic cancer

Perineural invasion (PNI), the infiltration of nerves by tumor cells, is a hallmark of pancreatic ductal adenocarcinoma (PDAC); however, despite being a clinically relevant phenomenon, the mechanisms underlying PNI remain poorly understood. Most currently available in vitro and ex vivo models rely on murine-sourced n...

Regina A. Casimiro-Núñez, Sydney Willey, Harrison L. Hiraki et al. · 0 citations
Sep 2026

Abstract A005: Deciphering the Hierarchy of Notch Signaling in Pancreatic Ductal Adenocarcinoma

Notch is a contact-dependent signaling pathway that plays critical roles in spatiotemporal patterning during embryogenesis. Beyond its role in development, Notch signaling regulates tissue patterning in adult organs in response to tissue injury or cancer. In the context of cancer, the role of Notch signaling has been...

Allison C. Bischoff, Wei Yan, Carlos E. Espinoza et al. · 0 citations

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