A Guarded Hybrid Pipeline for Rigid FLAIR–T1 MRI Registration: Learned Initialisation of Iterative Mutual-Information Refinement
Background: Rigid alignment of multimodal MRI is a prerequisite for neurological post-processing, yet classical iterative optimisers are accurate only when allowed to converge, at tens of seconds per volume, while learning-based predictors are fast but far less precise. This study asks whether a learned predictor can s...