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Author

F. Bratosin

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Review Open access Oct 2026

Plasma and Serum Metagenomic Sequencing of Microbial Cell-Free Nucleic Acids for Suspected Central Nervous System Infection: A Systematic Review

Background/Objectives: Untargeted metagenomic sequencing of microbial cell-free DNA or RNA in plasma or serum offers pathogen detection without lumbar puncture or biopsy, but its value in suspected central nervous system (CNS) infection is uncertain. We reviewed diagnostic yield, agreement with CNS-site testing, clinic...

F. Bratosin, H. Branea, Elena Hogea · 0 citations
Review Open access Oct 2026

Clinical Efficacy and Safety of Fosmanogepix in Patients with Invasive and Refractory Fungal Infections: A Systematic Review

Background: Fosmanogepix is a first-in-class Gwt1 inhibitor with oral and intravenous formulations and broad in vitro activity, but its clinical evidence is scattered across small trials and case reports. We reviewed all identifiable human data from the searched sources on its efficacy and safety in serious fungal infe...

F. Bratosin, Iulia Bogdan, S. Pescariu · 0 citations

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