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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

F. Cannac

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Open access Aug 2026

Consensus native-like hepatitis C virus E1E2 engages broadly neutralizing antibody precursors

A major goal for hepatitis C virus (HCV) vaccine development is to elicit broadly neutralizing antibodies (bNAbs) against the E1E2 glycoprotein complex located on the viral surface. Inducing HCV bNAbs requires engagement of their germline B cell precursors. HCV glycoproteins usually do not bind and activate inferred ge...

Fabian Mulder, F. Cannac, Joan Capella-Pujol et al. · 0 citations
Open access Jul 2026

Structure-based design of stable recombinant hepatitis C virus E1E2 heterodimers

Hepatitis C virus (HCV) affects 47 million people and causes 239,000 deaths annually, yet no vaccine is on the horizon. Generating a stable native-like mimic of the envelope complex E1E2, the only target for known neutralizing antibodies, is an important aim for HCV vaccine development. Starting from a recombinant E1E2...

Joan Capella-Pujol, Fabian Mulder, F. Cannac et al. · 1 citation
Open access Jul 2026

Membrane controlled Mechanoregulation in PIEZO1 Interactions

A systematic comparison is made between PIEZO1 reconstituted in detergent micelles and in cell membrane–derived nanodiscs, establishing native membranes as critical determinants for mechanotransduction.

Sanjai Karanth, Alessandro Nicoli, F. Cannac et al. · 0 citations

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