Author

F. De Smet

3 papers indexed here

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Sep 2026

Heterogeneous and conserved radiation responses reveal FOXM1-dependent regulation of microcephaly genes in glioblastoma

Glioblastoma (GBM) is characterized by marked heterogeneity, glioma stem-like cells (GSCs), and resistance to therapy. Because GSCs share features with neural progenitor cells (NPCs), we investigated whether neurodevelopmental programs contribute to their response to irradiation. Transcriptional profiling of four patie...

L. Van Eupen, E. Etlioglu, K. Tabury et al. · bioRxiv · 0 citations

Open access Aug 2026

Unravelling resistance mechanisms of oncolytic viruses in glioblastoma

Glioblastoma (GBM) is an aggressive primary brain tumor with a major unmet medical need. Oncolytic viruses (OVs) show promise for GBM treatment, but complete remissions remain rare. The intratumoral heterogeneity of GBM drives therapeutic escape and emergence of OV-resistant subclones. Beyond the well-characterized int...

T. Deconinck, T. Dierckx, F. De Smet et al. · bioRxiv · 0 citations

Open access Aug 2026

A compendium of next-generation patient-derived models for diverse cancers

The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models1,2. However, existing collections represent only a fraction of the diversity observed in human cancer2, 3–4. Recent technologies have enabled efficient in vitro model derivation (for example...

Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al. · Nature · 3 citations