Open access
Jul 2026
Stage-dependent effects of cognitive reserve on memory and brain structural integrity across the spectrum from healthy aging to Alzheimer’s disease
Findings support a stage-dependent model of CR, characterized by an additive protective role in healthy aging, patterns consistent with compensatory recruitment in early cognitive decline, and a possible loss of reserve effectiveness beyond a critical neuropathological threshold.
Laura Serra, Sabrina Bonarota, Giulia Caruso et al.
· Frontiers in Human Neuroscie... · 0 citations