Multiple long-term conditions (MLTC), the coexistence of two or more long-term conditions (LTCs) in an individual, is an increasingly prevalent and complex clinical challenge. We aimed to uncover opportunities for therapeutic intervention in MLTC and highlight potential adverse effects using genetics to identify shared...
B. Voller, R. Woodward, O. Murrin et al.· medRxiv· 0 citations
Mendelian randomisation (MR) implemented through instrumental variable (IV) analysis is a popular strategy for strengthening causal inference in observational studies. A key assumption for several MR estimators, including MR-Egger regression, is the INstrument Strength Independent of Direct Effect (INSIDE) assumption....
F. Hartwig, George Davey Smith, F. Dudbridge et al.· 0 citations
Risk factor 'weakness' after CHD appears to be a systemic phenomenon and consistent with the operation of index event bias, and broader progress in understanding subsequent event risk associations will require new methods that address index event bias.
L. Pasea, Spiros C. Denaxas, K. Tilling et al.· European Heart Journal· 1 citation
Background Despite multiple clinical trials, disease-modifying treatments for COPD are currently limited. Since many drugs target proteins, identifying causality between proteins and lung function informs understanding of COPD pathophysiology and may suggest novel targets. We used Mendelian randomisation (MR) to priori...
Jing Chen, N. Shrine, Kayesha Coley et al.· ERJ Open Research· 0 citations
BACKGROUND
Air pollution and diet both affect lung health and may interact. We investigated whether a healthy diet may modify associations between air pollution and lung function in adults.
METHODS
Modelled annual-average concentrations of nitrogen dioxide (NO2) and particulate matter with aerodynamic diameters ≤10 μ...
Pimpika Kaewsri, F. Dudbridge, J. Cade et al.· Environmental Research· 0 citations
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