OBJECTIVE
Tissue-specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue-derived pr...
Yue-Bei Luo, J. Kenrick, A. Galindo-Feria et al.· Arthritis & Rheumatology· 0 citations
Reading a protein’s sequence from tandem mass spectra without a reference is limited by single-spectrum accuracy, most acutely across the hypervariable complementaritydetermining regions of antibodies. Broadly specific proteases tile a protein with long, overlapping peptides, so every residue is covered by many indepen...
Alfred Nilsson, Emil Sporre, Douwe Schulte et al.· bioRxiv· 0 citations
Amyotrophic Lateral Sclerosis (ALS) is a phenotypically diverse neurodegenerative disorder characterized by the degeneration of motor neurons, ultimately resulting in loss of motor function. Currently, patients are classified based on clinical factors which does not fully capture the heterogeneity. Using the Olink Expl...
I. Aksoylu, L. Azizi, L. OÌijerstedt et al.· medRxiv· 0 citations
Systemic autoimmune rheumatic diseases (SARDs) are a heterogeneous group of autoimmune conditions characterized by immune system dysregulation leading to chronic inflammation and tissue damage. The overlapping clinical manifestations make differential diagnosis challenging, highlighting the need for novel biomarkers to...
J. Kenrick, C. Preger, M. B. Álvez et al.· Communications Medicine· 0 citations
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