Tuberculosis (TB) in adults can present in multiple ways. The lung is the most common site of disease, with cough, hemoptysis, weight loss, and night sweats as the most frequent symptoms. Extrapulmonary involvement, which may present many years after exposure, can affect virtually any organ. Microbiological sampling is...
F. Fama, Jessica L. Potter, Emily Shaw et al.· Cold Spring Harbor Perspecti...· 0 citations
Background Translation of tuberculosis (TB) biomarker and diagnostic research into tools that improve patient and public health outcomes has been slow, partly because no internationally agreed framework exists defining the use cases that new biomarkers and tests should address. We aimed to identify, validate, and prior...
S. Wright, F. Fama, A. de Wilton et al.· medRxiv· 0 citations
ABSTRACT Chronic pulmonary aspergillosis (CPA) is a progressive fungal infection associated with significant morbidity and mortality. Voriconazole, a standard first-line treatment, is limited by poor tolerability, unpredictable pharmacokinetics, and extensive drug-drug interactions. Isavuconazole, a newer triazole with...
F. Fama, Claudia Conflitti, A. Civati et al.· Antimicrobial Agents and Che...· 0 citations
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