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Sep 2026

Clinical Tuberculosis: Presentation and Diagnostic Approach.

Tuberculosis (TB) in adults can present in multiple ways. The lung is the most common site of disease, with cough, hemoptysis, weight loss, and night sweats as the most frequent symptoms. Extrapulmonary involvement, which may present many years after exposure, can affect virtually any organ. Microbiological sampling is...

F. Fama, Jessica L. Potter, Emily Shaw et al. · 0 citations
Review Open access Sep 2026

Defining use cases for biomarkers and tests across tuberculosis infection, disease and treatment: An international consensus and prioritisation exercise

Background Translation of tuberculosis (TB) biomarker and diagnostic research into tools that improve patient and public health outcomes has been slow, partly because no internationally agreed framework exists defining the use cases that new biomarkers and tests should address. We aimed to identify, validate, and prior...

S. Wright, F. Fama, A. de Wilton et al. · 0 citations
Open access Sep 2026

High frequency of isavuconazole use over voriconazole for chronic pulmonary aspergillosis: a retrospective observational study on tolerability and therapeutic drug monitoring

ABSTRACT Chronic pulmonary aspergillosis (CPA) is a progressive fungal infection associated with significant morbidity and mortality. Voriconazole, a standard first-line treatment, is limited by poor tolerability, unpredictable pharmacokinetics, and extensive drug-drug interactions. Isavuconazole, a newer triazole with...

F. Fama, Claudia Conflitti, A. Civati et al. · 0 citations

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