Real-world data support meta-analytic evidence and suggest that testosterone deficiency contributes to hepatic steatosis and fibrosis mainly through increased adiposity, while TRT may mitigate liver risk by modulating body composition and metabolic dysfunction.
G. Spaggiari, L. Valentina, C. Felicani et al.· European Journal of Endocrin...· 0 citations
A systematic review and meta-analysis supports a clinically relevant association between testosterone deficiency and MASLD, although evidence for the bidirectional nature of this relationship remains asymmetric but supports a clinically relevant endocrine-hepatic axis.
G. Spaggiari, L. Valentina, C. Felicani et al.· Andrology· 0 citations
Comprehensive genetic testing significantly enhances diagnostic accuracy, informs prognosis, and guides individualized management in adults with cryptogenic cholestasis, highlighting the need for multidisciplinary interpretation integrating clinical, biochemical, and genetic data.
Amalia Conti, F. Gabrielli, S. Ferrari et al.· Diagnostics· 0 citations
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