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Author

F. Gabrielli

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Open access Aug 2026

EP575 - ECE_1616 - Metabolic dysfunction–associated steatotic liver disease and testosterone serum levels: converging evidence from real-world observational data and meta-analysis

Real-world data support meta-analytic evidence and suggest that testosterone deficiency contributes to hepatic steatosis and fibrosis mainly through increased adiposity, while TRT may mitigate liver risk by modulating body composition and metabolic dysfunction.

G. Spaggiari, L. Valentina, C. Felicani et al. · 0 citations
Review Open access Jul 2026

The Bidirectional Association Between MASLD and Male Hypogonadism: An Updated Meta-Analysis.

A systematic review and meta-analysis supports a clinically relevant association between testosterone deficiency and MASLD, although evidence for the bidirectional nature of this relationship remains asymmetric but supports a clinically relevant endocrine-hepatic axis.

G. Spaggiari, L. Valentina, C. Felicani et al. · 0 citations
Review Open access Jul 2026

Use of Next-Generation Sequencing and Whole-Exome Sequencing in the Diagnosis of Adult-Onset Familial Intrahepatic Cholestasis: Challenges in Interpreting Variants of Uncertain Significance

Comprehensive genetic testing significantly enhances diagnostic accuracy, informs prognosis, and guides individualized management in adults with cryptogenic cholestasis, highlighting the need for multidisciplinary interpretation integrating clinical, biochemical, and genetic data.

Amalia Conti, F. Gabrielli, S. Ferrari et al. · 0 citations

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