F. Hölzle

Bone-adapted oral squamous cell carcinoma cells show adaptive responses to the osseous microenvironment in a murine tumor transplantation model

Bone invasion is a decisive step in the progression of oral squamous cell carcinoma (OSCC) and is associated with increased tumor aggressiveness, worsening the prognosis. Under the selection pressure of the bone microenvironment, a fundamental biological divergence arises. Bone-adapted cells represent not only a varian...