Open access
Jul 2026
Application of thermo-responsive polymers as an enema formulation for the treatment of ulcerative colitis.
A thermoresponsive and mucoadhesive dual-functionality enema system that enables injectable administration, in situ gelation, strong mucosal adhesion, and gradual release of 5-ASA while maintaining enhanced mucoadhesion and rectal retention, thereby improving retention and therapeutic potential.
Ena Hattanda, Narumi Maida, Kaoru Hirose et al.
· International journal of pha... · 0 citations