Open access
Sep 2026
Sequence and epigenetic characterization of chromosome 21 centromeres in a family with recurrent Trisomy 21
It is hypothesized that dCDRs may weaken kinetochore function, increasing nondisjunction risk, and proposed two models linking such epigenetic variation to maternal age-related T21 risk are proposed.
F. K. Mastrorosa, K. Hoekzema, Marcelo Ayllon et al.
· bioRxiv · 0 citations