Author

F. Klok

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Review Sep 2026

Safety of Age-Adjusted and Clinical Probability-Adjusted D-dimer Cut-offs in Suspected Pulmonary Embolism: A Systematic Review and Meta-Analysis.

BACKGROUND Adaptive D-dimer strategies for rule out of pulmonary embolism (PE) have been proposed to improve the efficiency of conventional fixed '500' D-dimer thresholds. Validations of adaptive D-dimer strategies post-hoc in cohorts managed according to the fixed D-dimer threshold seems to questions their safety. Res...

Mara Graziani, B. Akerboom, Y. Freund et al. · Chest · 1 citation

Review Open access Aug 2026

Risk-of-bias assessment in prognostic cohort studies: a methodological comparison study of structured appraisal tools in acute pulmonary embolism research

Structured tools for risk-of-bias assessment in prognostic cohort studies have variable reliability and limited agreement with expert appraisal, whereas ROBINS-I showed the strongest concordance with expert judgement, whereas QUIPS may provide optimistic ratings.

L. Cimini, F. Klok, M. Carrier et al. · BMJ Open · 0 citations