Mechanistic insight into SP1-mediated transcriptional activation of the long non-coding RNA MIR100HG.
MIR100HG is a long non-coding RNA (lncRNA) implicated in tumorigenesis and progression across multiple cancer types. In this study, SP1 expression was modulated by overexpression and stable silencing in Hep3B cells under normoxic and hypoxic conditions and verified at both the mRNA and protein levels. Functional assays...