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Author

F. Koser

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Open access Sep 2026

Nx3 Is a Z-Disk Structural and Signaling Hub That Is Reduced in Heart Failure.

BACKGROUND Nx3 (novex-3) is an exceptionally small isoform of the giant protein titin, whose structural and functional roles within the sarcomere remain poorly understood. METHODS AND RESULTS We used a comprehensive, multimodal approach to define the key properties of Nx3 in healthy and failing hearts, including its...

W. Linke, Lisa Kümper, A. Fomin et al. · 0 citations
Open access Aug 2026

Biallelic titin truncation disrupts sarcomere assembly and function in patient-derived iPSC-cardiomyocytes.

Using induced pluripotent stem cell-derived cardiomyocytes from a biallelic TTNtv patient with dilated cardiomyopathy, sarcomere structure/function is investigated and inefficient sarcomere assembly and interaction promotes cardiomyopathy in biallelic TTNtv.

Magnhild Sekse Erdal, Jing Qi, P. Erusappan et al. · 0 citations

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