Author

Fenna M. Krienen

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Sep 2026

Shared Transcriptional Features of Layer 3 Pyramidal Neurons Projecting to the Monkey Dorsolateral Prefrontal Cortex.

OBJECTIVE Layer 3 (L3) pyramidal neurons projecting to the primate dorsolateral prefrontal cortex (DLPFC) convey essential information for core cognitive processes. Alterations in these neurons could contribute to cognitive deficits in schizophrenia. This study was designed to determine whether DLPFC-projecting L3 pyra...

D. Arion, J. Enwright, F. Krienen et al. · American Journal of Psychiat... · 0 citations

Review Open access Sep 2026

GABAergic interneurons in local circuits of primate prefrontal cortex.

Cortical GABAergic interneurons exhibit remarkable diversity of morphological, electrophysiological and molecular features, which underlies their specialized roles in circuit functions. Molecular characteristics have proven to be a reasonable starting point in the past for classification, grouping them into parvalbumin...

S. Pommer, D. Lewis, F. Krienen et al. · Biological Psychiatry · 0 citations

Open access Aug 2026

PIANO: Probabilistic Inference Autoencoder Networks for multi-Omics enables robust generative modeling of gene expression and scales single-cell integration to 100 million cells

PIANO accurately integrates single-cell data across species and across single-cell and spatial transcriptomics modalities and models spatially-resolved gene expression during Alzheimer’s disease progression in human brains and integrates over 100 million cancer cells to model drug perturbations.

Ning Wang, Christopher Cardenas, Victor E. Nieto-Caballero et al. · bioRxiv · 0 citations