Rifampicin in Osteoarticular Infections: A Comprehensive Review of Current Evidence
Background. Osteoarticular infections (OAI)—including prosthetic joint infections (PJI), fracture-related infections (FRI), and osteomyelitis—are challenging to cure because bacterial biofilm on implant surfaces confers up to 1000-fold antibiotic tolerance, driving chronicity and relapse. Rifampicin, through its bacter...