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Author

F. Leser

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2 papers indexed here

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Open access Aug 2026

Cellular Prion Protein as a Novel Regulator of Vascular Plexus Stability During Retinal Angiogenesis

Angiogenesis is essential not only during embryogenesis but also in adult physiology and disease, relying on vascular endothelial growth factor (VEGF) gradients to guide tip cell sprouting. Cellular prion protein (PrPC), expressed in several neurovascular unit (NVU) cell types, regulates neuronal and astrocytic differe...

Bárbara Gomes da Rosa, F. Leser, Marco Aurélio Alves et al. · 0 citations
Open access Sep 2026

Cellular prion protein levels modulate nigrostriatal vulnerability to α-synuclein oligomers in Parkinson’s disease

α-Synuclein oligomer (αSynO)-mediated neurodegeneration is a hallmark of Parkinson’s disease (PD) pathogenesis, yet the molecular mechanisms mediating this toxicity remain elusive. In this study, we investigated the cellular prion protein (PrPC) as a key modulator of αSynO-induced neurodegeneration using an integrative...

Flavio de Souza Júnyor, F. Leser, Sarah de Souza Albuquerque et al. · 0 citations

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