Author

F. M. Stel

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Open access Jul 2026

Anti-capsid nanobodies function as HIV-1 capsid inhibitors by intracellular capsid degradation

A capsid-targeting biological composed of a single-domain Llama VHH that binds CA, fused to human IgG1 Fc to activate TRIM21-mediated degradation results in inhibition of viral replication through TRIM21-mediated proteasome degradation of the HIV-1 capsid, establishing capsid-directed biologicals as therapeutic strateg...

Floor M. Stel, Charlotte E. J. Verkuijlen, Esther M. Zijlstra-Willems et al. · Communications Biology · 1 citation

Open access Aug 2026

Capsid-Targeting Biologic Achieves Broad HIV-1 Neutralization with a High Barrier to Resistance

The results demonstrate the broad neutralization potential of anti-capsid biologics with a high barrier to resistance, making capsid-targeting inhibitors important for novel antiretroviral drug strategies worldwide.

F. M. Stel, E. Zijlstra-Willems, A. van Nuenen et al. · International Journal of Mol... · 0 citations