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Author

F. McMahon

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Open access Sep 2026

Selective vulnerability and resilience of thalamic neuronal populations in Frontotemporal Dementia

Abstract Frontotemporal dementia (FTD) caused by progranulin (GRN) mutations is associated with pronounced thalamic degeneration, yet the cellular basis of selective thalamic vulnerability remains poorly understood. Here, we generated an integrated single-nucleus RNA-sequencing atlas of the human antero-median thalamus...

Amber E. Trujillo, Mira Sohn, Magdalena J. Macias et al. · 0 citations
Open access Jul 2026

Time-dependent effects of rapid-acting antidepressants in iPSC-derived neurons from treatment-resistant depression and healthy volunteers.

This study is the first to assess multiple putative rapid-acting antidepressants in parallel using an iPSC-derived neuron model and observed convergent and drug-specific changes in gene expression and pathway enrichment, supporting the use of human iPSC-derived neurons in antidepressant drug discovery.

J. Johnston, Gregory H. Jones, Shiyong Peng et al. · 0 citations

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