F. Meyer-Almes

Boron‐Based Bioisosteres in Medicinal Chemistry: Advances in Heterocycles and Therapeutic

Overall, boron‐based bioisosteres represent a versatile platform for developing new therapeutics across diverse disease areas, including antifungal drugs such as tavaborole and crisaborole, as well as late‐stage candidates like epetraborole and acoziborole.

Discovery of cyanocarbonimidodithioates as novel non-hydroxamate zinc-binding groups for selective HDAC8 inhibition: Design, synthesis, biological evaluation, anticancer activity, and in silico studies.

Exploration of non-hydroxamate based quinoline analogues as HDAC8 inhibitors

Novel non-hydroxamate-based quinoline analogues were designed and explored as HDAC8-selective inhibitors that exhibit nanomolar HDAC8 enzymatic inhibition and establish these compounds as promising HDAC8 modulators with potential for therapeutic development in neuroblastoma.