Open access
Sep 2026
A chimeric murine coronavirus with altered deISGylase and proteolytic activities exhibits attenuated viral pathogenesis
ABSTRACT All coronaviruses encode one or two multifunctional papain-like proteases (PLPs) with protease activity that cleaves the viral polyprotein, along with deubiquitinating (DUB) and deISGylase activities that remove ubiquitin and interferon-stimulated gene 15 (ISG15) from viral and host proteins. Studying the role...
Mudassir S. Ali, A. O'Brien, En-Ya Qing et al.
· Journal of Virology · 0 citations