Author

F. Rassool

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Open access Sep 2026

Cryo-EM structures of autoinhibited and RNA-activated ZNFX1 helicase

ZNFX1 is an RNA helicase that plays a critical role in host defense against viral infections. Recent studies further revealed that ZNFX1 harbors an unexpected RNA-ubiquitinating E3 ligase activity, raising fundamental questions about how RNA-binding activates this multifunctional enzyme. Here, we combine cryo-electro...

Qing He, Feng Wang, F. Rassool et al. · Nature Communications · 0 citations

Open access Sep 2026

Uncovering pan-cancer signatures of chemoresistance

Chemotherapy resistance remains a formidable challenge in cancer treatment, driving high mortality rates worldwide. Despite significant advancements, it remains unclear whether conserved molecular programs underpin therapy resistance across cancer types. Here, we integrate single-cell RNA sequencing, spatial transcript...

Mohammed M. A. Inayatullah, Engin Demirdizen, Z. Keepers et al. · Genome Medicine · 0 citations

Open access Jul 2026

STING agonists in combination with epigenetic drugs potentiate ZNFX1-driven inflammatory necroptosis in TP53 -mutated AML

TP53-mutated acute myeloid leukemia (AML) has dismal outcomes with current treatments and represents a critical unmet need. TP53-mutated AML is proposed to be susceptible to immunotherapeutic approaches but, to date, there is no established immunotherapy for this sub-group. Expression of stimulator of interferon genes...

K. Tripathi, Lora Stojanovic, Zahra Gohari et al. · bioRxiv · 0 citations