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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

F. Roviezzo

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2 papers indexed here

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Open access Sep 2026

Sphingolipid metabolism contributes to sex dimorphism in COPD pathogenesis.

Sex-specific mechanisms in chronic obstructive pulmonary disease (COPD) remain poorly defined. Sphingolipids are bioactive mediators that regulate airway epithelial integrity, inflammation, and bronchial smooth muscle tone, and their dysregulation contributes to airway hyperresponsiveness. We tested whether sphingolipi...

Elisabetta Granato, Xiao-Yun Wang, Yun Zhang et al. · 0 citations
Open access Jul 2026

Identification of a New, Potent, and Stable Tetrahydroquinoline-Based 5‑LOX/sEH Dual Inhibitor with Polymodal Anti-Inflammatory Activity in Acute Pancreatitis

Findings reveal compound 11 as a promising anti-inflammatory agent supporting dual 5-LOX/sEH inhibition, coupled with Nrf2 activation, as a viable strategy for AP, showing potent in vitro inhibition of both enzymes and satisfactory metabolic stability.

D. D'Avino, T. Ciaglia, P. M. Jordan et al. · 0 citations

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