Author

F. Sahm

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Open access Sep 2026

Diagnosis and treatment decision of an IDH-mutant glioma through CSF-based cfDNA sequencing

Abstract Classification of tumors of the central nervous system currently requires tumor tissue analysis for histology and molecular markers, according to the 2021 WHO Classification of Tumors of the Central Nervous System. Cerebrospinal fluid (CSF)-based cell-free DNA (cfDNA) sequencing detects these defining molecula...

E. Fouarge, Rouzbeh Banan, S. Schulz et al. · Neuro-Oncology Advances · 0 citations

Preprint Aug 2026

DNA Methylation Profiling in Melanoma: From Lesion Classification to Therapeutic Stratification

It is demonstrated that methylation-based models can capture both diagnostic identity and clinically relevant disease stratification, supporting DNA methylation as a promising biomarker for further validation and potential clinical translation.

J. Winterstein, L. Heinlein, G. Raddatz et al. · 0 citations

Open access Aug 2026

31 CD44-Gal9 Interaction between IDH1-mutant Grade 4 Astrocytoma and Microglia Promotes Invasion and Proliferation of Tumor Cells

CD44-Gal9 signaling is identified as a clinically relevant axis promoting tumor invasiveness and immune evasion in IDH1-mutant astrocytomas andTherapeutic inhibition of this interaction may represent a promising strategy to simultaneously attenuate tumor aggressiveness and reprogram the tumor microenvironment.

Nathalie Große, F. Sahm, C. Herold-Mende et al. · Neuro-Oncology · 0 citations

Open access Aug 2026

50 Comparative evaluation of long- and short-read methylation-aware sequencing for CNS tumour diagnostics

Comparing methylation-aware sequencing platforms enabling simultaneous epigenomic and genomic profiling in CNS tumours shows robust cross-platform concordance and clinical feasibility for CNS tumour diagnostics.

S. Deacon, Inswasti Cahyani, Nadine Holmes et al. · Neuro-Oncology · 0 citations

Open access Jul 2026

Circulating tumor DNA precision oncology enables effective and sensitive molecular diagnostics and actionable target detection in pediatric solid tumors - the INFORM experience

By optimizing preanalytical and bioinformatic tools for pediatric settings, this study improved plasma-based cancer detection, molecular tumor characterization, and identification of targetable alterations, laying the groundwork for integration into personalized medicine programs and clinical trials.

K. Maass, P. Puranachot, S. Volz et al. · Genome Medicine · 0 citations