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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Francisco Sarabia

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Review Sep 2026

Strategy-based design for the identification of next generation β-lactam antibiotics that evade resistance from Gram-negative pathogens.

INTRODUCTION β-Lactam antibiotics have defined antibacterial chemotherapy for over eight decades and remain indispensable for the treatment of bacterial infections. Despite their clinical success, escalating antimicrobial resistance, particularly among Gram-negative pathogens, continues to impair their efficacy. This c...

Michio Kurosu, Iván Cheng-Sánchez, M. Aboulwafa et al. · 0 citations
Open access Jul 2026

Rationally Engineered, Chemically Stable Tunicamycin Analogues Decouple DPAGT1 Inhibition from Non-Selective Toxicity

Tunicamycin cyclitol analogues are established as a structurally distinct class of selective DPAGT1-targeted anticancer agents and it is demonstrated that stabilization of the glycosidic linkage is an effective strategy for enhancing pharmacological selectivity, improving in vivo performance, and simplifying the synthe...

Katsuhiko Mitachi, A. Sánchez‐Ruiz, D. Mingle et al. · 0 citations

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