The majority of metabolic pathways rely on the production of activated electrophilic intermediates, e.g., coenzyme-A esters, and their chemical structures and abundances are central to understanding enzyme function and biochemical mechanisms. However, most electrophilic metabolites are lost in traditional metabolomic a...
Allen F. Schroeder, Yan Yu, Ali Turk et al.· ACS Chemical Biology· 0 citations
Collective evidence from isotope tracing as well as genetic, dietary, and pharmacological manipulation experiments uncovered that C3-iminylation originates from cytochrome P450 (CYP)-mediated oxidation of omega-3 fatty acids, enabling further exploration of their biological and clinical implications.
Bing-Sen Zhang, Yu-Heng Hsieh, Tyler R. Bales et al.· Proceedings of the National...· 1 citation
AIMe (AI Molecule Explorer), a multi-agent neuro-symbolic AI framework that transforms the interpretation of unknown spectra into an omics-scale exploration across the known structural space, providing chemically interpretable annotations, is introduced.
U. U. Acikalin, Dieqiao Feng, Aaron M. Ferber et al.· bioRxiv· 0 citations
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