Author

F. Španiel

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Open access Oct 2026

From Gut to Brain: A Longitudinal Assessment of Intestinal Permeability and Immune Activation Markers in Early-Stage Schizophrenia Spectrum Disorders

Schizophrenia spectrum disorders (SSD) have been linked to immune dysregulation and altered intestinal barrier function, although findings across studies remain inconsistent. The present study investigated circulating markers of intestinal permeability and immune activation in individuals with early-stage SSD and healt...

L. Jakob, Tiziana Maria Mahayri, I. Koutrouli et al. · medRxiv · 0 citations

Open access Aug 2026

Genetic architecture of treatment-resistant schizophrenia across East Asian and European cohorts: insights from GWAS, TWAS, and synaptic pathway analyses

There is promise in pathway-level and multi-omics approaches to elucidate biologically meaningful heterogeneity within SSD and support for synaptic mechanisms as potential targets for understanding and stratifying treatment-resistance is provided.

P. B. Leung, K. C. Wong, S. Smart et al. · medRxiv · 0 citations

Open access Aug 2026

Medium-term prediction of clinically relevant outcomes in first-episode schizophrenia patients.

Negative symptoms are an exception: comparatively stable after initial treatment and predictable from baseline, with past symptomatology along with DUP selected as predictors - indicating stronger persistency and predictability than in the other two investigated outcomes.

E. Bakštein, J. Kúdelka, J. Schneider et al. · Schizophrenia Research · 0 citations