Author

F. Stenner

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Open access Sep 2026

Single-cell tracking reveals tumor-reactive T cell plasticity during melanoma TIL therapy.

Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) induces durable responses in metastatic melanoma, yet the clonal and transcriptional dynamics governing tumor-reactive T cell fate during ex vivo expansion and after transfer remain poorly understood. Here, we perform longitudinal single-cell RNA and T ce...

M. Sandholzer, Clara Serger, Alessia G. Liner et al. · Cell Reports Medicine · 0 citations

Open access Sep 2026

63 Th17 Signature Predicts Response to Dual Checkpoint Blockade in Metastatic Renal Cell Carcinoma

Abstract Background Combination immune checkpoint inhibition with anti-CTLA-4 and anti-PD-1 antibodies improves outcomes in metastatic renal cell carcinoma (mRCC), yet 40–60% of patients fail to achieve meaningful responses. Robust biomarkers that predict deep and durable responses are lacking. We aimed to define syste...

S. Guglietta, A. Bärenwaldt, Anthony Sonrel et al. · The Oncologist · 0 citations